Voprosy meditsinskoi khimii (ISSN 0042-8809)

Transport and metabolism of a membrane-active complexon in the mouse body

   
Plotnikova E.K., Golovenko N.Ia., Zin'kovskii V.G., Luk'ianenko N.G., Zhuk O.V.
PubMed Id: 3577059
Year: 1987 vol: 33  issue:1  pages: 62-66
Abstract: Two-phase decrease in content of N-(3H-aminoacetyl)-I-aza-4,7,10,11-tetraoxacyclopentadecane hydrochloride (ATCH) and of its metabolites as well as absence of accumulation were observed in mice tissues. Kinetic parameters of 3H-products elimination estimated by means of sequental logarithmation enabled to suggest that ATCH and its free metabolites were intensively involved in biotransformation of molecules. 3H-glycine was found not to be a product of the ATCH metabolism. High and stable level (from 10 min up to 24 hrs) of water soluble and protein-bound derivatives of ATCH were found in mice liver tissue and blood plasma after intravenous administration of the macroheterocycle.
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Reference: Plotnikova E.K., Golovenko N.Ia., Zin'kovskii V.G., Luk'ianenko N.G., Zhuk O.V., Transport and metabolism of a membrane-active complexon in the mouse body, Voprosy meditsinskoi khimii, 1987, vol: 33(1), 62-66.
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