Voprosy meditsinskoi khimii (ISSN 0042-8809)

Advantages of oxythiamine bromide as a specific inhibitor of activity of thiamine-dependent enzymes

   
Oparin D.A., Zimatkina T.I., Ostrovskiĭ I.M.
PubMed Id: 3577061
Year: 1987 vol: 33  issue:1  pages: 70-72
Abstract: Production of hydrogen bromide salt of hydroxythiamine (Ht. HBr) from thiamine bromide was developed its toxic and inhibitory properties towards transketolase and pyruvate dehydrogenase were studied as compared with commercial preparation hydroxythiamine chloride (HT. HCl). As compared with HT. HCl, synthesis of HT. HBr was more simple, the higher yield and purity of the end product were achieved. At the same time, the preparation was less toxic and exhibited the antivitaminous activity similar to the commercial chloride form.
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Reference: Oparin D.A., Zimatkina T.I., Ostrovskiĭ I.M., Advantages of oxythiamine bromide as a specific inhibitor of activity of thiamine-dependent enzymes, Voprosy meditsinskoi khimii, 1987, vol: 33(1), 70-72.
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