Voprosy meditsinskoi khimii (ISSN 0042-8809)

Effect of organic solvents on streptokinase-initiated fibrinolysis

   
Nikandrov V.N., Pyzhova N.S., Votiakov V.I.
PubMed Id: 3577065
Year: 1987 vol: 33  issue:1  pages: 84-87
Abstract: Proton-developing (ethanol, I-propanol, I-butanol, I-pentanol) and aproton solvents (dioxane, dimethylsulfoxide, dimethylformamide) at concentrations 1.5-50% activated the streptokinase-initiated fibrinolysis. Methanol and acetone were not effective. The rate of fibrinolysis, studied in presence of glycerol and phenol (used at 0.1-9.3% concentrations), depended on concentrations of these reagents in samples. Efficiency of aliphatic alcohols was increased with elongation of hydrocarbonic chain. The activating effect of ethanol was not removed by epsilon-aminocapronic acid 10(-2) M.
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Reference: Nikandrov V.N., Pyzhova N.S., Votiakov V.I., Effect of organic solvents on streptokinase-initiated fibrinolysis, Voprosy meditsinskoi khimii, 1987, vol: 33(1), 84-87.
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