Voprosy meditsinskoi khimii (ISSN 0042-8809)

Hypolipidemic action of the racemic methyl ester of 16,16-dimethyl-D-homo-8-isoestrone

   
Ryzhenkov V.E., Prokop'ev A.A., Nersisian G.G., Kameneva I.Yu., Shavva A.G.
PubMed Id: 3604144
Year: 1987 vol: 33  issue:2  pages: 65-68
Abstract: Racemic 16,16-dimethyl-D-homo-8-isoestrone methyl ester (substance 1) was shown to decrease the content of cholesterol in blood serum and liver tissue of animals with induced hyperlipidemia (rats, guinea pigs, rabbits) as well as to decrease the rate of atherosclerotic impairments in rabbit aorta. As distinct from usual estrogen, the substance I did not cause hypertriglyceridemia but normalized triglycerides in blood and liver tissue. Substance I exhibited low toxic effects.
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Reference: Ryzhenkov V.E., Prokop'ev A.A., Nersisian G.G., Kameneva I.Yu., Shavva A.G., Hypolipidemic action of the racemic methyl ester of 16,16-dimethyl-D-homo-8-isoestrone, Voprosy meditsinskoi khimii, 1987, vol: 33(2), 65-68.
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