Voprosy meditsinskoi khimii (ISSN 0042-8809)

The type of interaction of macrophages with serum low-density lipoproteins partially hydrolyzed by pepsin

   
Kovaleva G.G., Karmanskiĭ I.M.
PubMed Id: 3111086
Year: 1987 vol: 33  issue:2  pages: 83-86
Abstract: Effect of partial proteolysis of 125I-low density lipoproteins (LDL) from blood serum on their interaction with a culture of mice peritoneal macrophages was studied. Absorption and degradation of the LDL by macrophages was distinctly increased after 10% hydrolysis with pepsin. Degradation of 125I-LDL, hydrolyzed partially by pepsin, in the cells was less inhibited by unlabelled native LDL as compared with unlabelled but modified with pepsin LDL. Macrophages appear to contain specific sites for binding of LDL hydrolyzed partially by pepsin; these sites were distinct from receptors for acetylated LDL as shown by competitive analysis.
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Reference: Kovaleva G.G., Karmanskiĭ I.M., The type of interaction of macrophages with serum low-density lipoproteins partially hydrolyzed by pepsin, Voprosy meditsinskoi khimii, 1987, vol: 33(2), 83-86.
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