Voprosy meditsinskoi khimii (ISSN 0042-8809)

Induction of microsomal monooxygenases by an isopropyl derivative of aminopyrine

   
Gerasimov K.E., Tsyrlov I.B.
PubMed Id: 3604152
Year: 1987 vol: 33  issue:2  pages: 96-100
Abstract: As shown in the experiments with phenobarbital and chlorine isomers of naphthalene and biphenyl, the monooxygenase inductors of "phenobarbital" series caused their effect as unchanged molecules. Basing on this fact typical substrate of cytochrome P-450 aminopyrine was transformed into inductor of the enzyme biosynthesis by means of specific chemical modification of -N (CH3)2-group in the substrate molecule, which is N-demethylated in the enzyme active site. Effects of 4-isopropyl aminoantipyrine on the liver cell monooxygenase systems were studied. Synthesis of microsomal cytochrome P-450 was activated in liver tissue of rats, treated with 4-isopropyl aminoantipyrine, which was accompanied by simultaneous increase in the enzyme monooxygenase activity.
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Reference: Gerasimov K.E., Tsyrlov I.B., Induction of microsomal monooxygenases by an isopropyl derivative of aminopyrine, Voprosy meditsinskoi khimii, 1987, vol: 33(2), 96-100.
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