Voprosy meditsinskoi khimii (ISSN 0042-8809)

The state of the microsomal oxidative system in the liver of rats with acute osteomyelitis of the mandible

   
Nadzhimutdinov K.N., Azimov M.I., Krakovskiĭ M.E., Ashirmetov A.Kh.
PubMed Id: 3630001
Year: 1987 vol: 33  issue:3  pages: 101-104
Abstract: Duration of hexenal sleep and activity of main microsomal enzymes in hepatocytes were studied in experimental osteomyelitis of rat mandible. Within 7, 10 and 14 days after the osteomyelitis development content of cytochromes P-450 and b5 as well as activities of amidopyrine N-demethylase, aniline hydroxylase and NADPH cytochrome c reductase were decreased in liver cell microsomal fraction. As liver tissue monooxygenase enzymatic system is inhibited in osteomyelitis the elevated pharmacological activity and toxicity of drugs, metabolized in liver tissue, should be considered under conditions of practical use of these drugs.
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Reference: Nadzhimutdinov K.N., Azimov M.I., Krakovskiĭ M.E., Ashirmetov A.Kh., The state of the microsomal oxidative system in the liver of rats with acute osteomyelitis of the mandible, Voprosy meditsinskoi khimii, 1987, vol: 33(3), 101-104.
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