Voprosy meditsinskoi khimii (ISSN 0042-8809)

Metabolic pool of purine and pyrimidine derivatives in the palatine tonsil of patients with chronic tonsillitis

   
Toguzov R.T., Tikhonov I.V., Pimenov A.M., Markusheva L.I.
PubMed Id: 3660732
Year: 1987 vol: 33  issue:4  pages: 112-115
Abstract: Tonsils from 10 patients (18-40 years old), with chronic tonsillitis were studied by means of histological methods as well as by high pressure liquid chromatography. In 5 patients with decompensated forms of the disease, accompanied by heart impairments during 1-3 years, only slight alterations in epithelial and follicular parts of tonsils were observed, while pronounced destruction of tonsil cells was detected in other 5 patients suffering from repeated anginas. The following purine and pyrimidine derivatives were identified in faucial tonsil tissue of all the patients with chronic tonsillitis studied: adenine, guanine, adenosine, guanosine, inosine and uridine. Distinct increase in content of these derivatives as well as occurrence of xanthine and uric acid (non-identified in the first group of patients with chronic tonsillitis) was noted in the patients with maximal destruction of faucial tonsil cells.
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Reference: Toguzov R.T., Tikhonov I.V., Pimenov A.M., Markusheva L.I., Metabolic pool of purine and pyrimidine derivatives in the palatine tonsil of patients with chronic tonsillitis, Voprosy meditsinskoi khimii, 1987, vol: 33(4), 112-115.
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