Voprosy meditsinskoi khimii (ISSN 0042-8809)

The role of cell membrane damage in the development of hormone-resistant kidney diseases in children

   
Krylov V.I., Petrushina A.D., Moreva G.V., Grannik G.K., Durygin A.N.
PubMed Id: 3660735
Year: 1987 vol: 33  issue:4  pages: 22-24
Abstract: Distinct increase in content of lysophosphatidyl choline, dehydrocholesterol, decrease in concentration of phosphatidyl ethanolamine simultaneously with high level of diene conjugates and Schiff bases were found in children with hormone-resistant form of nephrotic glomerulonephritis as compared with children suffering from a hormone-dependent form of the disease. Peroxidation of membrane lipids appears to cause a destabilization of cell membranes, which is responsible for development of hormone-resistance.
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Reference: Krylov V.I., Petrushina A.D., Moreva G.V., Grannik G.K., Durygin A.N., The role of cell membrane damage in the development of hormone-resistant kidney diseases in children, Voprosy meditsinskoi khimii, 1987, vol: 33(4), 22-24.
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