Voprosy meditsinskoi khimii (ISSN 0042-8809)

Na,K-ATPase from the outer kidney medulla of spontaneously hypertensive rats in ontogenesis

   
Boldyrev A.A., Orlov S.N., Svinukhova I.A., Stetsiuk N.U.
PubMed Id: 2821696
Year: 1987 vol: 33  issue:4  pages: 56-59
Abstract: Specific activity of Na,K-ATPase from kidney outer medulla microsomes of spontaneously hypertensive rats (SHR) and of normotensive Kyoto-Wistar rats (WKY) at different stages of ontogenesis was studied. A positive correlation was observed between the blood pressure level and specific Na,K-ATPase activity in SHR kidney medulla. At the malignant stage of the disease, the specific activity of Na,K-ATPase exceeded that of control by 67%. The inhibiting effect of blood serum from SHR on purified preparations of Na,K-ATPase was far more pronounced than that of WKY.
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Reference: Boldyrev A.A., Orlov S.N., Svinukhova I.A., Stetsiuk N.U., Na,K-ATPase from the outer kidney medulla of spontaneously hypertensive rats in ontogenesis, Voprosy meditsinskoi khimii, 1987, vol: 33(4), 56-59.
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