Voprosy meditsinskoi khimii (ISSN 0042-8809)

Comparative study of the RNA-polymerase activity of non-pathogenic and pathogenic influenza viruses A and B

   
Pravdina N.F., Podcherniaeva R.Ya., Skovorodka V.V., Galegov G.A., Zhdanov V.M.
PubMed Id: 3660748
Year: 1987 vol: 33  issue:4  pages: 86-89
Abstract: Activity of RNA polymerase was studied in original non-pathogenic for mice viruses of influenza A and B (A/seal/Massachusetts 1/80, A/USSR 05/81, A/Philippines 2/82 and B/Singapore 227/79) and of their pathogenic derivatives. All the non-pathogenic viruses studied exhibited the low rate of transcriptase activity. Pathogenic derivatives of these strains exhibited higher activity of RNA polymerase, which was 1.5-3-fold higher as compared with the original strain. During passage of influenza viruses A and B in mice organism selection of the population appears to occur, which had the highest transcriptase activity.
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Reference: Pravdina N.F., Podcherniaeva R.Ya., Skovorodka V.V., Galegov G.A., Zhdanov V.M., Comparative study of the RNA-polymerase activity of non-pathogenic and pathogenic influenza viruses A and B, Voprosy meditsinskoi khimii, 1987, vol: 33(4), 86-89.
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