Voprosy meditsinskoi khimii (ISSN 0042-8809)

Changes in carbohydrate metabolism during experimental alcoholic liver disease

   
Gil'miiarova F.N., Sidorenkov I.V., Radomskaia V.M., Vinogradova L.N., Mikhailova N.N.
PubMed Id: 3686892
Year: 1987 vol: 33  issue:5  pages: 131-134
Abstract: Decrease in activities of alcohol dehydrogenase and catalase, inhibition of mitochondrial glycerophosphate-, lactate-, malate-, succinate dehydrogenases as well as a decrease in the pool of oxidized nicotinamide coenzymes were observed in liver tissue of rabbits after per oral administration of 30% ethanol within two months. Ratios of substrates of tricarboxylic acid cycle were altered: concentrations of malate and oxaloacetate were decreased and content of alpha-ketoglutarate exceeded distinctly the normal level. Content of glucose, pyruvic and lactic acids were also decreased in liver tissue.
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Reference: Gil'miiarova F.N., Sidorenkov I.V., Radomskaia V.M., Vinogradova L.N., Mikhailova N.N., Changes in carbohydrate metabolism during experimental alcoholic liver disease, Voprosy meditsinskoi khimii, 1987, vol: 33(5), 131-134.
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