Voprosy meditsinskoi khimii (ISSN 0042-8809)

Activity of lysosomal proteolytic enzymes in rat gastric mucosa during contrical administration

   
Dzodzuashvili V.U.
PubMed Id: 2446426
Year: 1987 vol: 33  issue:5  pages: 84-85
Abstract: Contrical was shown to decrease distinctly the activity of cathepsins A, B, C and D in rat gastric mucosa in situ and in vitro. At the same time, application of contrical as a polymeric complex with glue MK-8 resulted in penetration of the drug into the incubation mixture and led to inhibition of lysosomal proteinases. The data obtained suggest that simultaneous use of contrical and glue MK-8 may serve as an adequate therapeutic approach in local treatment of gastroduodenal ulcers.
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Reference: Dzodzuashvili V.U., Activity of lysosomal proteolytic enzymes in rat gastric mucosa during contrical administration, Voprosy meditsinskoi khimii, 1987, vol: 33(5), 84-85.
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