Voprosy meditsinskoi khimii (ISSN 0042-8809)

Chemical structure and immunostimulating activity of high molecular weight polysaccharides

   
Sinilova N.G., Duplishcheva A.P., Romashevskaia E.I., Mysiakin E.B., Tumanian M.A.
PubMed Id: 2451350
Year: 1987 vol: 33  issue:6  pages: 103-107
Abstract: An immunostimulating activity of high molecular polysaccharides, dissimilar in their chemical structure, was studied. Inoculation of mice with bacteria of typhoid fever and Kl. pneumoniae demonstrated that O-polysaccharide from typhoid bacteria--multicomponent, branch-chained, phosphorus-containing polysaccharide--exhibited the highest immunostimulating effect. Mannans and glucans, with linear and branch-chained molecules, involving various types of C-C bonds, had lower stimulating properties, which did not correlate with the level of a molecule branching and the type of C-C bonds. These data were confirmed after evaluation of adjuvant properties of high molecular polysaccharides with sheep erythrocytes and their ability to activate macrophages.
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Reference: Sinilova N.G., Duplishcheva A.P., Romashevskaia E.I., Mysiakin E.B., Tumanian M.A., Chemical structure and immunostimulating activity of high molecular weight polysaccharides, Voprosy meditsinskoi khimii, 1987, vol: 33(6), 103-107.
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