Voprosy meditsinskoi khimii (ISSN 0042-8809)

Effect of beta-mercaptoethylamine on tryptophan hydroxylase activity in rat tissues

   
Graevskaia E.E., Lomakin N.N., Mineeva M.F., Goncharenko E.N.
PubMed Id: 3445535
Year: 1987 vol: 33  issue:6  pages: 107-110
Abstract: The ability of amine-producing tissues (liver tissue, small intestine, mast cells) of rats to synthesize 5-hydroxytryptophan in response to irradiation and their involvement in creation of endogenous radioresistance was studied. Administration of a thiol radioprotector beta-mercaptoethylamine resulted in alteration of kinetic properties of tryptophane hydroxylase expressed as a decrease in the optimal concentration of the substrate; this decrease was more distinct in liver and small intestine as compared with mast cells.
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Reference: Graevskaia E.E., Lomakin N.N., Mineeva M.F., Goncharenko E.N., Effect of beta-mercaptoethylamine on tryptophan hydroxylase activity in rat tissues, Voprosy meditsinskoi khimii, 1987, vol: 33(6), 107-110.
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