Voprosy meditsinskoi khimii (ISSN 0042-8809)

Effect of different inactivating agents on microsomal cytochromes P-450 and P-448

   
Poliakova N.E., Gromova O.A., Tsyrlov I.B.
PubMed Id: 3445541
Year: 1987 vol: 33  issue:6  pages: 27-31
Abstract: The properties of tert-butanol, sodium deoxycholate, guanidine and mersalyl to convert microsomal cytochromes P-450 and P-448 into enzymatically inactive form P-420 were studied under comparable conditions. Phenobarbital-induced cytochrome P-450 was especially sensitive to the influence of all the agents studied, while cytochrome P-450 from untreated animals was the least sensitive; the 3-methyl-cholanthrene-induced cytochrome P-448 exhibited the least sensitivity to guanidine. The dynamics of changes in content of active and inactive hemoprotein forms after in vitro treatment with the suitable agent might serve as a criterion for estimation whether the phospholipid or protein component of microsomal membrane was damaged.
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Reference: Poliakova N.E., Gromova O.A., Tsyrlov I.B., Effect of different inactivating agents on microsomal cytochromes P-450 and P-448, Voprosy meditsinskoi khimii, 1987, vol: 33(6), 27-31.
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