Voprosy meditsinskoi khimii (ISSN 0042-8809)

Effect of retabolyl and oxymetacyl on protein metabolism in experimental burns in immature rats

   
Davletov E.G., Saliakhova R.M., Kamilov F.Kh.
PubMed Id: 3445545
Year: 1987 vol: 33  issue:6  pages: 51-56
Abstract: Impairments of protein metabolism, expressed as predominance of catabolism over anabolism and hypoproteinemia, were observed in one month old rats with experimental burns of the IIIA-IIIB degree, when 20-25% of a body surface was impaired. After administration of steroid drugs (retabolyl at a dose of 1 mg/100 g of body mass or oxymetacyl--4-methyl-5-oxyuracil---at a dose of 5 mg/100 g of body mass) content of protein and urea normalized in blood serum, activity of cathepsin D decreased in tissues, the rate of 35S-methionine incorporation into tissue proteins increased. The pyrimidine derivative oxymetacyl exhibited higher effect on protein metabolism in burns of preadolescent rats as compared with retabolyl.
Download PDF:
Reference: Davletov E.G., Saliakhova R.M., Kamilov F.Kh., Effect of retabolyl and oxymetacyl on protein metabolism in experimental burns in immature rats, Voprosy meditsinskoi khimii, 1987, vol: 33(6), 51-56.
References
 1995(Vol:41)
 1994(Vol:40)
 1993(Vol:39)
 1992(Vol:38)
 1991(Vol:37)
 1990(Vol:36)
 1989(Vol:35)
 1988(Vol:34)
 1987(Vol:33)
 1986(Vol:32)