Voprosy meditsinskoi khimii (ISSN 0042-8809)

Surface properties and size of very low and low density lipoproteins in human plasma in normal states and in hypercholesterolemia

   
Vozyan P.A., Kholodova Iu.D., Smirnova I.P., Chobot'ko G.M.
PubMed Id: 3369119
Year: 1988 vol: 34  issue:1  pages: 101-105
Abstract: Dimensions and density of surface charge of very low (VLDL) and low density lipoproteins (LDL) from hyman blood plasma under conditions of normal state and hypercholesterolemia were evaluated by means of radiation-free energy transition between fluorescent probes and potentiometric titration. Radia of VLDL constituted 13.9 +/- 0.6 nm and 20.7 +/- 1.2 nm and those of LDL--10.0 +/- 0.5 nm and 12 +/- 0.4 nm, respectively, in normal state and under the pathological conditions, while the density of surface charge of VLDL was equal to 0.5 X X 10(-2)K/m2 and 0.3.10(-2)K/m2; those of LDL--0.2.10(-2)K/m2 and 0.05.10(-2)K/m2, respectively. These alterations appear to facilitate the unspecific interaction between atherogenic lipoproteins and vascular cells in hypercholesterolemia.
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Reference: Vozyan P.A., Kholodova Iu.D., Smirnova I.P., Chobot'ko G.M., Surface properties and size of very low and low density lipoproteins in human plasma in normal states and in hypercholesterolemia, Voprosy meditsinskoi khimii, 1988, vol: 34(1), 101-105.
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