Voprosy meditsinskoi khimii (ISSN 0042-8809)

Free radical mechanism of homogentisic acid in alkaptonuria

Gerasimov A.M., Zakharov A.S.
PubMed Id: 2835867
Year: 1988 vol: 34  issue:1  pages: 112-115
Abstract: Non-enzymatic oxidation in alkaline media of homogentisinic acid, excreted with urine in alkaptonuria, involved free radical mechanism. The oxidative process was accompanied by production of superoxide anion O2- and required metal cations. Free radical destruction of cells and biopolymers via O2- or homogentisinic acid semiquinone appears to be one of pathogenetic mechanisms responsible for impairment of connective tissue structures in patients with alkaptonuria.
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Reference: Gerasimov A.M., Zakharov A.S., Free radical mechanism of homogentisic acid in alkaptonuria, Voprosy meditsinskoi khimii, 1988, vol: 34(1), 112-115.