Voprosy meditsinskoi khimii (ISSN 0042-8809)

Pharmacokinetics of dalargin

   
Kalenikova E.I., Dmitrieva O.F., Korobov N.V., Zhukovskiĭ S.V., Tishchenko V.A., Vinogradov V.A.
PubMed Id: 3369130
Year: 1988 vol: 34  issue:1  pages: 75-83
Abstract: Pharmacokinetics of a new anti-ulcer drug, synthetic opioid hexapeptide dalargin (Tyr-D-Ala-Gly-Phe-Leu-Arg), which is an analogue of Leu-enkephalin, was studied in rats. Distribution and metabolism of 3H-Tyr-dalargin were examined after intravenous administration at a dose of 150 mg/kg. Main Tyr-containing metabolites of dalargin were detected and dynamics of their concentrations was evaluated in blood within 1 hr after administration. Kinetic curve of dalargin was described as three-exponential function.
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Reference: Kalenikova E.I., Dmitrieva O.F., Korobov N.V., Zhukovskiĭ S.V., Tishchenko V.A., Vinogradov V.A., Pharmacokinetics of dalargin, Voprosy meditsinskoi khimii, 1988, vol: 34(1), 75-83.
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