Voprosy meditsinskoi khimii (ISSN 0042-8809)

Metabolism of vitamin D in exogenous hypercorticism in rats

   
Karatabanova N.A., Arkhapchev Yu.P., Sergeev I.N., Linberg L.F., Spirichev V.B.
PubMed Id: 3259348
Year: 1988 vol: 34  issue:1  pages: 83-86
Abstract: Short-term administration of hydrocortisone into rats (within 7 days) stimulated 1.25(OH)2D3 synthesis in kidney and led to accumulation of the metabolite in blood serum, small intestinal mucose and bones. After long-term administration of hydrocortisone within 28 days synthesis of 1.25(OH2D3) was decreased in kidney while the content of 24.25(OH)2D3 was was simultaneously increased. Concentration of labelled 1.25 (OH)2D3 and 24.25(OH)2D3 was distinctly decreased in small intestinal mucose and femur bones.
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Reference: Karatabanova N.A., Arkhapchev Yu.P., Sergeev I.N., Linberg L.F., Spirichev V.B., Metabolism of vitamin D in exogenous hypercorticism in rats, Voprosy meditsinskoi khimii, 1988, vol: 34(1), 83-86.
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