Voprosy meditsinskoi khimii (ISSN 0042-8809)

Fluorometric titration in a method of metabolic cooperation in the differential diagnosis of mucopolysaccharidoses

   
Lebedeva T.V., Odinokova O.N., Krasnopol'skaia K.D., Freidin M.I.
PubMed Id: 3135667
Year: 1988 vol: 34  issue:2  pages: 117-119
Abstract: Content of intracellular glycosaminoglycans (GAG) was studied in a procedure of metabolic cooperation by means of the polysaccharides fluorimetric titration in order to differentiate between various types of mucopolysaccharidoses and to establish prenatal diagnosis of these diseases. The procedure involved electrostatic interaction of fluorochrome 4,6-diamidino-2-phenylindol. HCl with GAG's. As compared with the standard radiometric method of metabolic cooperation the procedure developed exhibited higher sensitivity, which is especially important for differentiation of the mucopolysaccharidoses III (A, B, C, D) and for prenatal diagnosis of these diseases.
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Reference: Lebedeva T.V., Odinokova O.N., Krasnopol'skaia K.D., Freidin M.I., Fluorometric titration in a method of metabolic cooperation in the differential diagnosis of mucopolysaccharidoses, Voprosy meditsinskoi khimii, 1988, vol: 34(2), 117-119.
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