Voprosy meditsinskoi khimii (ISSN 0042-8809)

Protein level and Na,K-ATPase activity of rat kidney tissues following cis-platin administration

   
Reznik L.V., Miazina E.M., Natochin Yu.V.
PubMed Id: 2840770
Year: 1988 vol: 34  issue:2  pages: 26-29
Abstract: Concentrations of protein and electrolytes as well as activity of Na,K-ATPase were studied in renal tissue of rats within 5 days after cisplatinum administration (5 mg/kg of body mass, intraperitoneally). There were a significant reduction in the ATPase activity and an increase in water content and sodium concentration in renal cortex tissue, while K+, Ca2+ and Mg2+ were unaltered. At the same time, concentration of electrolytes did not shift in blood serum and muscle tissue. After intraperitoneal administration of choline chloride at a dose of 290 mg/kg of body mass within 40 min before the cisplatinum treatment less distinct alterations were observed in the urea content and in the Na,K-ATPase activity.
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Reference: Reznik L.V., Miazina E.M., Natochin Yu.V., Protein level and Na,K-ATPase activity of rat kidney tissues following cis-platin administration, Voprosy meditsinskoi khimii, 1988, vol: 34(2), 26-29.
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