Voprosy meditsinskoi khimii (ISSN 0042-8809)

The role of the antithrombin III-heparin-thrombin complex in the defense reaction of the anticoagulation system

   
Kudriashov B.A., Liapina L.A., Pastorova V.E.
PubMed Id: 3400189
Year: 1988 vol: 34  issue:2  pages: 38-42
Abstract: Complexes antithrombin III-heparin-thrombin exhibiting the anticoagulation and nonenzymatic fibrinolytic activities were isolated from human blood children of 4-II years old with burns or with traumatic shock and from rat blood. The complexes antithrombin III-heparin-thrombin with high nonenzymatic fibrinolytic activity were shown to develop during activation of the anticoagulation system. In depression of the anticoagulation system these complexes, isolated from blood, demonstrated the lower nonenzymatic fibrinolytic activity, thus indicating that complex-formation is restricted.
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Reference: Kudriashov B.A., Liapina L.A., Pastorova V.E., The role of the antithrombin III-heparin-thrombin complex in the defense reaction of the anticoagulation system, Voprosy meditsinskoi khimii, 1988, vol: 34(2), 38-42.
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