Voprosy meditsinskoi khimii (ISSN 0042-8809)

Lysosomal hydrolase activity of the rat liver, spleen and thymus during antigenic stimulation and vitamin B6 deficiency

   
Vasil'ev A.V., Konovalova L.S., Pletsityi K.D., Ponomareva L.G., Tutel'ian V.A.
PubMed Id: 3400200
Year: 1988 vol: 34  issue:2  pages: 97-99
Abstract: Activity of cathepsins A, B, C and D and protein half-life T1/2 in rat liver, spleen and thymus tissues, content of antibody-producing cells in spleen, titer of antibodies and the complement activity were studied after antigen stimulation accompanied by vitamin B6 deficiency. Deficiency of vitamin B6 caused a distinct decrease in immune response and in activation of thiol-dependent proteinases in thymus, while the enzymatic activity was lowered in liver tissue. At the same time, the protein T1/2 was increased by 39% in liver tissue and decreased by 36% in thymus. These data suggest the importance of lysosomal thiol-dependent proteinases in immunogenesis.
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Reference: Vasil'ev A.V., Konovalova L.S., Pletsityi K.D., Ponomareva L.G., Tutel'ian V.A., Lysosomal hydrolase activity of the rat liver, spleen and thymus during antigenic stimulation and vitamin B6 deficiency, Voprosy meditsinskoi khimii, 1988, vol: 34(2), 97-99.
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