Voprosy meditsinskoi khimii (ISSN 0042-8809)

High molecular weight L-asparaginase derivatives based on a water-soluble carboxymethyl cellulose: biological properties

   
Karsakevich A.S., Kinstler O.B., Dauvarte A.Kh., Vina I.A.
PubMed Id: 3420797
Year: 1988 vol: 34  issue:3  pages: 107-110
Abstract: L-asparaginase, covalently bound with water-soluble CM-cellulose, exhibited the elevated antileukemic activity in mice with inoculated lymphoid leukemia L5178y as compared with the native enzyme. The antileukemic activity of the immobilized enzyme was shown to depend on the content of the polymer bound with the enzyme; the polymer amount may be altered during the enzyme modification. The prolonged effect of immobilized L-asparaginase was observed in rabbit circulation.
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Reference: Karsakevich A.S., Kinstler O.B., Dauvarte A.Kh., Vina I.A., High molecular weight L-asparaginase derivatives based on a water-soluble carboxymethyl cellulose: biological properties, Voprosy meditsinskoi khimii, 1988, vol: 34(3), 107-110.
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