Voprosy meditsinskoi khimii (ISSN 0042-8809)

The state of calcium homeostasis in the blood in patients with psoriasis during a period of enhanced epidermopoiesis

   
Goncharenko M.S., Kondakova A.K., Brodskaia O.M.
PubMed Id: 3420809
Year: 1988 vol: 34  issue:3  pages: 42-45
Abstract: As a model of generalized impairments of the membrane structure in patients with psoriasis, an "erythrocyte-blood plasma" system was used for studies of calcium homeostasis. Distinct accumulation of Ca2+ in erythrocytes and reduction of Ca2+ content in blood plasma were observed in patients with psoriasis, thus demonstrating its redistribution between cells and medium. This Ca2+ transfer occurred due to an increase of Na+ concentration in the cells, which caused a decrease in the rate of Ca2+ excretion and led to elevation of the ion content in cytoplasmic fraction. The elevated intracellular concentration of Ca2+ in patients with psoriasis contributed to activation of lipid peroxidation as well as to selective increase in permeability of erythrocyte membranes for K+. The data obtained suggest that a number of alterations in homeostasis of calcium may be considered among the factors responsible for activation of cellular proliferation in the patients with psoriasis.
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Reference: Goncharenko M.S., Kondakova A.K., Brodskaia O.M., The state of calcium homeostasis in the blood in patients with psoriasis during a period of enhanced epidermopoiesis, Voprosy meditsinskoi khimii, 1988, vol: 34(3), 42-45.
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