Voprosy meditsinskoi khimii (ISSN 0042-8809)

A study of thermoinduced changes in human high-density lipoproteins in hypo-alpha-lipoproteinemia and ischemic heart disease by the spin label method

   
Gorshkova I.N., Noeva E.A., Polesskiĭ V.A., Perova N.V., Ruuge E.K.
PubMed Id: 2844020
Year: 1988 vol: 34  issue:3  pages: 85-90
Abstract: Thermo-induced structural reorganization in human high density lipoproteins subclasses HDL2 and HDL3 have been studied by means of electronic paramagnetic resonance method. A number of spin labels were used: 5- and 16-DOXYL stearates, DOXYL-labelled derivatives of pentadecane, phosphatidyl choline and sphingomyelin. In hypoalphalipoproteinemia one of the thermo-induced transitions in HDL2 (at 23-30 degrees) was not observed. In coronary heart disease the critical temperature for HDL3 was shifted from the physiological values and located at 42-48 degrees. The data obtained are discussed from the point of view of their potential role in atherogenesis.
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Reference: Gorshkova I.N., Noeva E.A., Polesskiĭ V.A., Perova N.V., Ruuge E.K., A study of thermoinduced changes in human high-density lipoproteins in hypo-alpha-lipoproteinemia and ischemic heart disease by the spin label method, Voprosy meditsinskoi khimii, 1988, vol: 34(3), 85-90.
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