Voprosy meditsinskoi khimii (ISSN 0042-8809)

Differences between collagens of the the interstitial type and their effect on the biosynthesis of DNA and RNA and activity of various enzymes in biopsy specimens of wound tissues in rats

   
Zaĭdenberg M.A., Andreev V.I.
PubMed Id: 2458654
Year: 1988 vol: 34  issue:3  pages: 97-100
Abstract: Effect of collagen soluble forms of the I and III types on biosynthesis of DNA, RNA on activity of adenylate and guanylate cyclase as well as on activity of several key enzymes of energy metabolism was studied in bioptic samples of wound granulation tissue and in homogenates of intact rat liver tissue in vitro. Effects of the collagen soluble forms were shown to depend on their type and the step of wounds healing. Collagen of the III type stimulated DNA and RNA biosynthesis inhibited adenylate cyclase and activated guanylate cyclase within 3 days after the operation. Activities of lactate-, malate-, glucose-6-phosphate dehydrogenases and creatine phosphokinase were also dissimilarly altered in presence of collagens of the I and III types. The data obtained suggest that collagens of the I and III types affected dissimilarly the metabolic processes in wound tissues within various steps of their healing.
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Reference: Zaĭdenberg M.A., Andreev V.I., Differences between collagens of the the interstitial type and their effect on the biosynthesis of DNA and RNA and activity of various enzymes in biopsy specimens of wound tissues in rats, Voprosy meditsinskoi khimii, 1988, vol: 34(3), 97-100.
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