Voprosy meditsinskoi khimii (ISSN 0042-8809)

The effect of vitamin K deficiency in rats on various enzyme systems participating in energy metabolism

   
Kolesova G.M., Sokol'nikov A.A., Kodentsova V.M., Klimova O.A., Sergeev I.N.
PubMed Id: 3195131
Year: 1988 vol: 34  issue:4  pages: 46-51
Abstract: In alimentary deficiency of vitamin K in rats, accompanied by an increase in the prothrombin time by 30%, activity of kidney creatine kinase and of blood serum alkaline phosphatase was unaltered, while the activity of alkaline phosphatase in small intestinal mucose was decreased by 20% and that of creatine kinase from skeletal muscles--by 10%. In vitamin K-deprived animals the rate of coupling between respiration and mitochondrial phosphorylation was decreased, which might be due to alteration in the NADH-dehydrogenase complex. Menadion reductase activity and cyanide-resistant respiration of mitochondria were unaltered in presence of menadion. Palmitic acid effectively activated of mitochondrial respiration in vitamin K-deprived animals (contrary to the control rats). This effect appears to occur as a result of structural alterations in mitochondria depending on vitamin K level in the organelles.
Download PDF:
Reference: Kolesova G.M., Sokol'nikov A.A., Kodentsova V.M., Klimova O.A., Sergeev I.N., The effect of vitamin K deficiency in rats on various enzyme systems participating in energy metabolism, Voprosy meditsinskoi khimii, 1988, vol: 34(4), 46-51.
References
 1995(Vol:41)
 1994(Vol:40)
 1993(Vol:39)
 1992(Vol:38)
 1991(Vol:37)
 1990(Vol:36)
 1989(Vol:35)
 1988(Vol:34)
 1987(Vol:33)
 1986(Vol:32)