Voprosy meditsinskoi khimii (ISSN 0042-8809)

Effect of chemical modification of hemoglobin on its biological activity

   
Gudkin L.R., Kuznetsova N.P., Samsonov G.V., Mishaeva R.N., Stragovich L.M.
PubMed Id: 3195138
Year: 1988 vol: 34  issue:4  pages: 90-93
Abstract: Oligomeric hemoglobins were produced after polycondensation with glutaric aldehyde (OHb) as well as after modification with pyridoxal-5-phosphate (OHb-PLP). OHb exhibited high affinity to oxygen (P50 = 17 torr) as well as a decreased rate of the subunits cooperative interaction (n = 1.5-1.6); OHb-PLP possessed P50 = 27 torr, n = 2.2 (for pO2 greater than P50), Bore effect -0.4. The P50 pattern was not distinctly altered in presence of approximately 15% Met hemoglobin, while already 8% of the Met form affected the "n" parameter. Biological activity of OHb and OHb-PLP was studied.
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Reference: Gudkin L.R., Kuznetsova N.P., Samsonov G.V., Mishaeva R.N., Stragovich L.M., Effect of chemical modification of hemoglobin on its biological activity, Voprosy meditsinskoi khimii, 1988, vol: 34(4), 90-93.
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