Voprosy meditsinskoi khimii (ISSN 0042-8809)

Effect of silimarine on activity of lysosomal proteinases in the liver and kidneys during tetramethylthiuram disulfide administration

   
Tabagari S.I., Shubitidze T.M., Abdushelishvili G.V.
PubMed Id: 3064406
Year: 1988 vol: 34  issue:5  pages: 110-113
Abstract: Total and nonsedimented activities of lysosomal proteinases were studied in rat liver and kidney tissues after administration of silimarine simultaneously with tetramethylthiuram disulfide (TMTD). Silimarine did not affect the pattern of alterations in total activity of lysosomal proteinases, caused by the TMTD treatment, but the nonsedimented activity of the enzymes studied was normalized. Silimarine appears to exhibit the membrane-stabilizing effect.
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Reference: Tabagari S.I., Shubitidze T.M., Abdushelishvili G.V., Effect of silimarine on activity of lysosomal proteinases in the liver and kidneys during tetramethylthiuram disulfide administration, Voprosy meditsinskoi khimii, 1988, vol: 34(5), 110-113.
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