Voprosy meditsinskoi khimii (ISSN 0042-8809)

Prevention of atherogenic dislipoproteinemias and metabolic disorders in the liver in emotional-pain stress

   
Meerson F.Z., Tverdokhlib V.P., Nikonorov A.A.
PubMed Id: 3238931
Year: 1988 vol: 34  issue:6  pages: 104-109
Abstract: Atherogenous dislipoproteinemia, involving a decrease in HDL cholesterol and 3-4-fold increase in the atherogeneity index was found to develop in rats after emotional-pain-dependent stress. Lipid peroxidation was activated in liver tissue of the animals, which was expressed as an increase in the MDA content, a decrease in SOD activity and as marked activation of fructose I-phosphate aldolase, an enzyme specific for liver tissue, in blood serum. The impairment of liver tissue caused an inhibition of 7 alpha-cholesterol hydroxylase--key enzyme of cholesterol hydroxylation into bile acids; the phenomenon may be of importance in development of dislipoproteinemias. Preadaptation of the animals to moderate hypoxia as well as administration of an antioxidant ionol prevented the activation of lipid peroxidation in liver tissue, liberation of fructose I-phosphate aldolase into blood, depression of 7 alpha-cholesterol hydroxylase and protected against the stress-dependent atherogenous dislipoproteinemia. Possible chemical and adaptational protection of liver, which is a very stress-sensitive tissue, is discussed.
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Reference: Meerson F.Z., Tverdokhlib V.P., Nikonorov A.A., Prevention of atherogenic dislipoproteinemias and metabolic disorders in the liver in emotional-pain stress, Voprosy meditsinskoi khimii, 1988, vol: 34(6), 104-109.
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