Voprosy meditsinskoi khimii (ISSN 0042-8809)

Glucocorticoid receptors of the liver and blood lymphocytes in acute cholecystitis

   
Golikov P.P., Nikolaeva N.Yu., Spiridonov I.V., Skliarevskiĭ V.V.
PubMed Id: 3238941
Year: 1988 vol: 34  issue:6  pages: 36-39
Abstract: Cholecystectomy was carried out in 31 patients with acute cholecystitis within 5-7 days after percutaneous transliver microcholecystotomy. During the operation biopsy was taken from bed of gallbladder and liver left lobe for histological studies. In a part of the biopsy material glucocorticoid receptors of the II and III types were studied, simultaneously with detection of some metabolites and cortisol in blood plasma. Glucocorticoid receptors of the II type were estimated in lymphocytes. Content of glucocorticoid receptors of the II type constituted 20.1 fmole.mg-1 of protein and 16.0 fmole.mg-1 of protein in liver cytosol and in liver bed of gallbladder, respectively; content of the receptors of the III type was equal to 268.0 fmole mg-1 and 329.0 fmole.mg-1 of protein in liver tissue and in liver bed of gallbladder, respectively. In lymphocytes 1223 glucocorticoid receptors of the II type were estimated as compared with 4100 receptors in the cells of healthy persons. Distinct increase in the level of cortisol, cholesterol, glucose and urea was observed in the patients, while total protein and protein fractions were similar to control values. Possible role of glucocorticoid receptors in pathogenesis of acute cholecystitis is discussed.
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Reference: Golikov P.P., Nikolaeva N.Yu., Spiridonov I.V., Skliarevskiĭ V.V., Glucocorticoid receptors of the liver and blood lymphocytes in acute cholecystitis, Voprosy meditsinskoi khimii, 1988, vol: 34(6), 36-39.
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