Voprosy meditsinskoi khimii (ISSN 0042-8809)

Inhibitory effect of 3'-azido-3'-azido-3'-deoxy- ribavirin-5'-triphosphate on RNA synthesis catalyzed by RNA polymerase from influenza A virus and by cellular DNA-dependent RNA polymerase II

   
Pravdina N.F., Galegov G.A.
PubMed Id: 2472705
Year: 1989 vol: 35  issue:1  pages: 104-106
Abstract: Inhibitory effect of 3'-azide-3'deoxy-ribavirin-5'-triphosphate on activity of RNA-dependent RNA polymerase from influenza A virus as well as on DNA-dependent RNA polymerase II from mice liver nuclei was studied. The drug inhibited effectively RNA synthesis catalyzed by these enzymes, whereas its most selective inhibitory action was found in reaction with RNA polymerase from influenza A virus.
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Reference: Pravdina N.F., Galegov G.A., Inhibitory effect of 3'-azido-3'-azido-3'-deoxy- ribavirin-5'-triphosphate on RNA synthesis catalyzed by RNA polymerase from influenza A virus and by cellular DNA-dependent RNA polymerase II, Voprosy meditsinskoi khimii, 1989, vol: 35(1), 104-106.
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