Voprosy meditsinskoi khimii (ISSN 0042-8809)

Modification of the streptokinase functional groups during iodination

Nikandrov V.N., Kaziuchits O.A.
PubMed Id: 2741398
Year: 1989 vol: 35  issue:1  pages: 41-47
Abstract: Modification of tyrosine residues was detected in streptokinase molecule during iodination. A nonlinear type of the modification reaction allowed to suppose that tyrosine residues were heterogenous. As shown by gel chromatography the modified streptokinase did not develop stable complexes with human plasminogen even at low ratios of iodine/streptokinase, however the activating effects of the streptokinase were maintained. During iodination the secondary structure of streptokinase appears to be altered, the level of which depended on the molar ratio iodine/streptokinase.
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Reference: Nikandrov V.N., Kaziuchits O.A., Modification of the streptokinase functional groups during iodination, Voprosy meditsinskoi khimii, 1989, vol: 35(1), 41-47.