Voprosy meditsinskoi khimii (ISSN 0042-8809)

The cyclic nucleotide system in various sections of the dog myocardium in experimental infarction

   
Frolova N.Iu., Printsev M.D., Tret'iakov A.V., Kozhetiakin L.A., Korovkin B.F.
PubMed Id: 2568032
Year: 1989 vol: 35  issue:1  pages: 64-68
Abstract: Distinct increase and then decrease in content of cyclic nucleotides was observed in dog myocardium ventricles and auricles within early periods of heart infarction (10 min-4 hrs). Within a day after ligation of artery the ratio cAMP/cGMP was considerably decreased as a result of activation of guanylate cyclase and cAMP-phosphodiesterase as well as due to a decrease in activity of adenylate cyclase. Acute ischemia of small area of the heart left ventricle caused impairment of cyclic nucleotide metabolism in all the heart muscle.
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Reference: Frolova N.Iu., Printsev M.D., Tret'iakov A.V., Kozhetiakin L.A., Korovkin B.F., The cyclic nucleotide system in various sections of the dog myocardium in experimental infarction, Voprosy meditsinskoi khimii, 1989, vol: 35(1), 64-68.
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