Voprosy meditsinskoi khimii (ISSN 0042-8809)

Activity of 5-alpha- and 5-beta-steroid reductases in subcellular liver structures from rats bearing Walker carcinosarcoma

   
Ulinskaĭte A.P., Krauialis K.I., Diashrius A.P.
PubMed Id: 2741400
Year: 1989 vol: 35  issue:1  pages: 77-81
Abstract: Change in the activity of cytoplasmic 5 beta- and microsomal 5 alpha-steroid reductases was studied in tumor bearing rats. As shown by thin-layer chromatography conversion of 3H-corticosterone into 5-alpha and 5 beta-dihydro-compounds was decreased 3-fold in rats bearing Walker tumor. Activity of both these enzymes exceeded the initial level 2-3-fold in presence of exogenous NADPH. At the same time, activation of glucose 6-phosphate dehydrogenase was accompanied by simultaneous alteration in content of transcortin-bound corticosterone in rat blood plasma. 5 alpha-reductase was detected in membranes of liver tissue endoplasmic reticulum and in the fraction of free polyribosomes.
Download PDF:
Reference: Ulinskaĭte A.P., Krauialis K.I., Diashrius A.P., Activity of 5-alpha- and 5-beta-steroid reductases in subcellular liver structures from rats bearing Walker carcinosarcoma, Voprosy meditsinskoi khimii, 1989, vol: 35(1), 77-81.
References
 1995(Vol:41)
 1994(Vol:40)
 1993(Vol:39)
 1992(Vol:38)
 1991(Vol:37)
 1990(Vol:36)
 1989(Vol:35)
 1988(Vol:34)
 1987(Vol:33)
 1986(Vol:32)