Voprosy meditsinskoi khimii (ISSN 0042-8809)

Changes in the sensitivity of the adrenoreactive systems of various subtypes in rheumatic fever in children

   
Kulinskiĭ V.I., Chesmochakova E.I.
PubMed Id: 2787075
Year: 1989 vol: 35  issue:1  pages: 88-91
Abstract: Distinct and generalized decrease in sensitivity of alpha 2-adrenoreactive system, pronounced decrease of beta 1- and beta 2-but not of alpha 1-adrenoreactivity were observed in children with acute rheumatic fever. After cupping of the rheumatic attack and restoration of circulation functions impairments of the alpha 2-adrenoreactivity (but not of beta 1- and beta 2-adrenoreactivities) were decreased however without complete normalization. Absence of a number of sympathogenic reactions appears to occur due to impairment of the adrenoreactive system sensitivity even though accumulation of catecholamines as found in biological fluids, as a result of which catecholamine-effector uncoupling elevated.
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Reference: Kulinskiĭ V.I., Chesmochakova E.I., Changes in the sensitivity of the adrenoreactive systems of various subtypes in rheumatic fever in children, Voprosy meditsinskoi khimii, 1989, vol: 35(1), 88-91.
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