Voprosy meditsinskoi khimii (ISSN 0042-8809)

Absorption of C14-labeled dye 'active red 5CX'++ immobilized on polysaccharides in the rat gastrointestinal tract

   
Shatrov G.N., Gmoshinskiĭ I.V., Zaĭtsev A.N.
PubMed Id: 2741403
Year: 1989 vol: 35  issue:1  pages: 95-99
Abstract: Rats were maintained on a diet containing 14C-aniline procion dye 'active red 5CX' either in a hydrolyzed or chemically immobilized form on starch and cellulose. Absorption of the label, distribution in tissues and excretion were studied within 6-48 hrs. Independently on the forms of the preparation used more than 80% of the label occurred in blood and were then excreted with urine. Molecule of the azo-dye appears to degrade in large intestine by means of microflora with splitting of the azo-bond and the potentially toxic metabolites developed penetrated into a body media. Immobilization of the dye on polymers, including cellulose was not an effective approach to prevent these reactions.
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Reference: Shatrov G.N., Gmoshinskiĭ I.V., Zaĭtsev A.N., Absorption of C14-labeled dye 'active red 5CX'++ immobilized on polysaccharides in the rat gastrointestinal tract, Voprosy meditsinskoi khimii, 1989, vol: 35(1), 95-99.
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