Voprosy meditsinskoi khimii (ISSN 0042-8809)

Polymorphism of human genes, methods of its detection and relation with cardiovascular diseases (review of the literature)

   
Surguchev A.P.
PubMed Id: 2662598
Year: 1989 vol: 35  issue:2  pages: 16-23
Abstract: The data on human gene polymorphism in connection to cardiovascular diseases are reviewed. Special attention is paid to the genes encoding apolipoproteins, the components of lipoprotein particles that play an important role in lipid transport and metabolism. Besides, the data on polymorphic forms of genes, encoding LDL-receptor, enzymes, participating in lipid metabolism and other genes relevant to the development of certain pathologies of cardiovascular system are presented. Possibilities of use of the information on the gene polymorphism for diagnostic purposes and for understanding the molecular mechanisms of the disease are discussed.
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Reference: Surguchev A.P., Polymorphism of human genes, methods of its detection and relation with cardiovascular diseases (review of the literature), Voprosy meditsinskoi khimii, 1989, vol: 35(2), 16-23.
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