Voprosy meditsinskoi khimii (ISSN 0042-8809)

Regeneration ability of ischemic liver and the effect of liver resection and extracts stimulating proliferation

   
Bilenko M.V., Seregina L.A., Komarov N.G., Abakumova O.Yu.
PubMed Id: 2741422
Year: 1989 vol: 35  issue:2  pages: 93-97
Abstract: DNA synthesis was studied in liver nuclei of Wistar rats after 30% liver tissue resection, 2 hr ischemia of 70% liver tissue or 2 hr ischemia of 70% liver tissue with resection of intact lobes. DNA synthesis was markedly increased in ischemic lobes and was especially high in ischemic lobes if simultaneous resection of intact lobes occurred; maximum of the synthesis was observed within 32 hrs after the operation. Proliferation stimulating extracts, isolated from liver tissue within 48 hrs after the resection or after ischemia, intensified the regenerating processes in the resected liver tissue; the first preparation (from resected liver tissue) exhibited the most distinct effect as compared with the second extract (from ischemic liver tissue). Proliferation stimulating extracts did not affect the cytochrome P-450, content of which was decreased after resection and ischemia. The data obtained suggest the important role of proliferation stimulating factors in regeneration of liver tissue after ischemia or resection; these factors proved to be possible to isolate from ischemized and reperfused liver tissue; the medicinal effect of resection was shown.
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Reference: Bilenko M.V., Seregina L.A., Komarov N.G., Abakumova O.Yu., Regeneration ability of ischemic liver and the effect of liver resection and extracts stimulating proliferation, Voprosy meditsinskoi khimii, 1989, vol: 35(2), 93-97.
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