Voprosy meditsinskoi khimii (ISSN 0042-8809)

The effect of nerve growth factor, guanethidine and their combined use on nuclease activity in animal tissues

   
Kaliunov V.N., Petrusenko G.P., Fomichenko K.V.
PubMed Id: 2773375
Year: 1989 vol: 35  issue:3  pages: 117-120
Abstract: Activity of ribo- and deoxyribonucleases RNAases I and II, DNAases I and II was studied in brain hemispheres, liver, kidney and heart tissues of one-month-old rats, which were administered daily, beginning from birth either with nerve growth factor 15 micrograms/kg, guanethidine 30 micrograms/kg or with these compounds simultaneously at the doses mentioned above. Activity of the nucleases studied was altered in nervous tissue and in vegeto-dependent tissues after separate treatment with both nerve growth factor and guanethidine, while their simultaneous administration caused slight normalization but not to complete recovery of the patterns studied.
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Reference: Kaliunov V.N., Petrusenko G.P., Fomichenko K.V., The effect of nerve growth factor, guanethidine and their combined use on nuclease activity in animal tissues, Voprosy meditsinskoi khimii, 1989, vol: 35(3), 117-120.
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