Voprosy meditsinskoi khimii (ISSN 0042-8809)

Change in carbohydrate metabolism, secretion of insulin and glucagon in normoglycemic rats during administration of various doses of nicotinamide

   
Krylov Yu.F., Kononenkko T.L., Smirnov P.A., Tigranian R.A., Kalita N.F., Melkonian A.G.
PubMed Id: 2528238
Year: 1989 vol: 35  issue:3  pages: 30-32
Abstract: Development of hypoglycemia, a slight decrease in concentration of glucagon in blood as well as increase in activity of malate-and glucose-6-phosphate dehydrogenases in liver cytosol were detected in rats injected subcutaneously with nicotinamide at a dose of 31.25 mg/kg 6 hrs before decapitation. Increase of the single dose up to 125 mg/kg caused hypoglycemia, distinct increase in concentration of insulin and glucagon in blood plasma simultaneously with a pronounced inhibition of the enzymatic activity in liver tissue. Effect of nicotinamide on carbohydrate metabolism appears to have a dissimilar character depending on the drug dose: its small doses accelerated utilization and oxidation of glucose but did not affect the secretion of insulin and glucagon.
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Reference: Krylov Yu.F., Kononenkko T.L., Smirnov P.A., Tigranian R.A., Kalita N.F., Melkonian A.G., Change in carbohydrate metabolism, secretion of insulin and glucagon in normoglycemic rats during administration of various doses of nicotinamide, Voprosy meditsinskoi khimii, 1989, vol: 35(3), 30-32.
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