Voprosy meditsinskoi khimii (ISSN 0042-8809)

Intensity of gluconeogenesis in the rat liver in the recovery period after long-term hypokinesis

   
Ershikov S.M.
PubMed Id: 2773385
Year: 1989 vol: 35  issue:3  pages: 55-58
Abstract: Gluconeogenesis was studied in liver tissue of 60 rats within the period of readaptation after 60 days of hypokinesia. Biosynthesis of glucose from alanine, aspartic-, glutamic-, alpha-ketoglutaric and pyruvic acids as well as from glycerol was distinctly inhibited as a result of long-term hypokinesia. Stimulation of gluconeogenesis was noted during the beginning of the readaptation period within 1-7 days, which caused the "superrestoration" of glycogen content in liver tissue. The rate of glucose synthesis was decreased within the later period (15 days) of readaptation. The specific properties of the restoration period should be considered in working out of the rehabilitation courses.
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Reference: Ershikov S.M., Intensity of gluconeogenesis in the rat liver in the recovery period after long-term hypokinesis, Voprosy meditsinskoi khimii, 1989, vol: 35(3), 55-58.
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