Voprosy meditsinskoi khimii (ISSN 0042-8809)

Change in nucleic acid synthesis in the spleen of rats with acute deficit of vitamin B1 during immunogenesis

   
Dvorianinovich L.N.
PubMed Id: 2475977
Year: 1989 vol: 35  issue:3  pages: 92-96
Abstract: After four administrations of human blood serum gamma-globulin (intraperitoneally, once during 4 days at a dose of 1 mg and the following reimmunization within 60 days at a dose of 3-4 mg) distinct incorporation of 14C-thymidine (specific activity 54 muCi/mumole, by 5 muCi per an animal, 2 hrs before decapitation, intraperitoneally) into rat spleen DNA was detected within 4 days of immunogenesis. Acute oxythiamine B1 avitaminosis (single subcutaneous administration of oxythiamine at a dose of 400 mg/kg) led to a decrease in the label incorporation into spleen DNA of immunized rats by 70% (p less than 0.01) as compared with control immunized animals, while incorporation of 14C-thymidine was unaltered in intact rats. Content of RNA was not distinctly altered in spleen of B1-deficient rats within the 4 days of immunogenesis. Acute deficiency of vitamin B1 thus impaired synthesis of DNA in spleen during development of immunogenesis.
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Reference: Dvorianinovich L.N., Change in nucleic acid synthesis in the spleen of rats with acute deficit of vitamin B1 during immunogenesis, Voprosy meditsinskoi khimii, 1989, vol: 35(3), 92-96.
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