Voprosy meditsinskoi khimii (ISSN 0042-8809)

Mechanism of regulation of tyrosine metabolism in ethanol poisoning

Kurbanov K.K., Romakh O.N.
PubMed Id: 2573195
Year: 1989 vol: 35  issue:4  pages: 102-105
Abstract: Metabolism of tyrosine was impaired after chronic alcoholization of rats with 10% ethanol within 10 months. Within the first 3-4 months activation of tyrosine aminotransferase and a decrease in phenylalanine hydroxylase activity were found in liver tissue. Activity of tyrosine aminotransferase was not increased during the long-term alcohol intoxication. At the same time, activity of tyrosine aminotransferase was decreased within 5-6 months simultaneously with activation of phenylalanine hydroxylase. An increase in the alcohol dehydrogenase activity was also observed in rat liver tissue during the initial period of intoxication. The enzymatic activity was decreased beginning from the 3-4 months of the alcoholization and maintained at the low level. Hyperthermia augmented these alterations observed in chronic alcoholization of rats.
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Reference: Kurbanov K.K., Romakh O.N., Mechanism of regulation of tyrosine metabolism in ethanol poisoning, Voprosy meditsinskoi khimii, 1989, vol: 35(4), 102-105.