Voprosy meditsinskoi khimii (ISSN 0042-8809)

Intensification of the diabetogenic effect of alloxan by protamine sulfate

   
Kudriashov B.A., Ul'ianov A.M., Tarasov Iu.A.
PubMed Id: 2815670
Year: 1989 vol: 35  issue:4  pages: 128-131
Abstract: Administration of protamine sulfate into circulation was shown to increase the diabetogenic effect of alloxan. Protamine sulfate bound endogenous heparin, as a result of which the diabetogenic factor caused more severe forms of experimental diabetes. At the same time, the diabetogenic factor exhibited distinctly higher activity during the heparin deficiency developed.
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Reference: Kudriashov B.A., Ul'ianov A.M., Tarasov Iu.A., Intensification of the diabetogenic effect of alloxan by protamine sulfate, Voprosy meditsinskoi khimii, 1989, vol: 35(4), 128-131.
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