Voprosy meditsinskoi khimii (ISSN 0042-8809)

Myocardial damage and the sympatho-adrenal system in ethanol abstinence syndrome in rats

   
Nuzhnyĭ V.P., Tezikov E.B., Zabirova I.G., Ugriumov A.I.
PubMed Id: 2815672
Year: 1989 vol: 35  issue:4  pages: 16-20
Abstract: Increase in content of II-oxycorticosteroids and in activity of dopamine-beta-hydroxylase in blood serum, decrease in concentration of adrenaline in adrenal glands with simultaneous accumulation of the catecholamine in myocardium were observed in rats after intensive alcoholization within 5 days (intragastric administration of ethanol 4-5 g/kg twice daily). In this case content of noradrenaline and its density in the catecholamine-containing nervous fibers were decreased. Ethanol abolishing, as shown by dynamics of catecholamines in heart and adrenal glands, caused an additive stimulation of the sympathoadrenal system, which reached the maximal level within a day and accomplished within 3 days after the last ethanol injection. Abolishing of ethanol led to an increase in the rate of creatine kinase elimination from isolated perfused heart and to activation of the enzyme in rat blood, which reached the maximal value within 3-7 days after the last injection of ethanol. Development of myocardium impairments correlated with accumulation of catecholamines in extraneuronal structures of heart tissue.
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Reference: Nuzhnyĭ V.P., Tezikov E.B., Zabirova I.G., Ugriumov A.I., Myocardial damage and the sympatho-adrenal system in ethanol abstinence syndrome in rats, Voprosy meditsinskoi khimii, 1989, vol: 35(4), 16-20.
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