Voprosy meditsinskoi khimii (ISSN 0042-8809)

Changes in the rate of lecithin cholesterol acyltransferase reaction and lipid indicators of serum under the effect of cathergene in acute experimental liver damage

   
Gaskina T.K., Kurilovich S.A., Gorchakov V.N.
PubMed Id: 2815674
Year: 1989 vol: 35  issue:4  pages: 24-28
Abstract: Fractional and molar rates of lecithin:cholesterol aminotransferase (LCAT)-catalyzed reaction were decreased, while free cholesterol fraction was increased in blood serum of rats within 24 hrs after single administration of CCl4 I mg/kg. Cathergene, contributing to a decrease in hepatocyte necrosis, affected positively the blood lipid spectrum in CCl4 treated rats. The cathergene protective effect, observed also after acute ethanol poisoning (6 g/kg), involved an increase by about 30% of the fractional and molar rates of LCAT-reactions; it also normalized the cholesterol esterification coefficient in blood serum. The drug did not prevent the postalcohol dystrophy of hepatocytes, hypertriglyceridemia, hypercholesterolemia.
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Reference: Gaskina T.K., Kurilovich S.A., Gorchakov V.N., Changes in the rate of lecithin cholesterol acyltransferase reaction and lipid indicators of serum under the effect of cathergene in acute experimental liver damage, Voprosy meditsinskoi khimii, 1989, vol: 35(4), 24-28.
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